Category Archives: Cancer Treatment

Lung Cancer Numbers Rise in Female Non-Smoking Populations

Cancer Rising in Female Non-Smokers
Cancer is Rising in Female Non-Smokers

As the most common form of the disease worldwide, lung cancer is a primary target of immunotherapy for cancer research and testing. Unfortunately, scientists are alarmed at the rising incidence of lung cancer in women and non-smokers.

Non-Smokers Are Not Immune to Lung Cancer

The link between tobacco and lung cancer is well-known, leaving many people to mistakenly believe that only smokers will develop the disease. The facts are that approximately 15 percent of lung cancer cases are non-tobacco-related.

This anomaly is especially pronounced among women. Studies show that 20 percent of women who are diagnosed with lung cancer are lifelong non-smokers, compared to only 10 percent of men. Data from the U.K. reveals that, among patients undergoing lung cancer surgery over a six-year period, women made up 67 percent of the group that had never smoked.

Lung Cancer and the Gender Gap

In another dubious distinction, lung cancer rates in women have risen over the last 20 years, even as they’ve fallen in men. Researchers attribute this development to two possible causes:

– There is some evidence that women’s DNA is more vulnerable to damage caused by carcinogens contained in tobacco.

– At one time, smoking among women was relatively rare. Gains in gender equality appear to have resulted in more women taking up the habit.

Scientists urge anyone who experiences symptoms such as unexplained coughing, chest pains and shortness of breath to see their doctor, even if they’ve never smoked.

Immunotherapy for Cancer: When Other Treatments Have Failed

Our personalized immunotherapy for cancer programs have helped patients with both primary lung cancer and lung metastases. Contact us for more information.

Test on New Drug that Contains Cancer Cell Metastasis

Tests on New Drugs That May Provide Better Treatment
Tests on a New Drug That May Contain the Spread of Cancer

At Issels®, our immunotherapy for cancer treatments are often used with patients whose tumors have spread to other parts of the body. Over the last few years, an international research team has made significant progress in developing a drug that limits the movement of cancer cells.

Stopping the Spread of Cancer Cells

Metastasis is the term for the ability of cancer cells to move throughout the body and establish tumors in locations away from the primary site. Once a tumor metastasizes, it presents a greater challenge for successful treatment.

While cancer research primarily focuses on treating tumors directly, a multinational team of scientists decided to investigate possible methods of interfering with cancer cells’ motility. If migration could be contained, it would help prevent tumors from entering later, hard-to-treat stages.

KBU2046: Putting the Brakes on Metastasis

In 2011, the team identified a drug called KBU2046 that binds to heat-shock proteins found in all cells, preventing cell movement. Original testing was done on human cell models of breast, prostate, lung and colon cancer in vitro.

The team’s most recent study, published in June, extended testing to mouse models. Scientists were able to confirm that KBU2046 targeted cancer cells only, sparing healthy tissue, and further refinements eliminated any side effects.

The researchers believe that the positive results justify their unorthodox approach. Next step on their agenda is obtaining funds to conduct further studies in preparation for clinical trials.

Integrative Immunotherapy Treatments for Late-Stage Cancer

Numerous patients with advanced and therapy-resistant tumors have achieved long-term remission with our personally developed immunotherapy for cancer programs. Visit our website to hear and read their first-person testimonials.

Tel Aviv University Nanoprobes Light Up Stray Cancer Cells

New Cancer Research Is Improving Cancer Treatment
New Cancer Research Is Improving Cancer Treatment

While cancer treatment often includes surgery, even a few missed cells can lead to recurrence and metastasis. Recent development of a “smart probe” that pinpoints cancer cells may greatly improve the effectiveness of surgical options.

Challenges of Surgery as Cancer Treatment

Removal of solid tumors can still leave behind stray cells that evade detection by MRI or CT. In some cases, surgeons end up damaging otherwise healthy tissue in an effort to excise all diseased cells.

Extensive studies by an interdisciplinary team at Tel Aviv University culminated in development of a nanoprobe that literally shines a light on cancer cells. When injected into a patient a few hours before surgery begins, the probe can alert the surgeon to the presence of cancer cells that might have been missed.

“Shedding a Light” on Cancer Cells

The probe is activated by the presence of an enzyme known as cysteine cathepsins, which occurs in higher numbers in tumor cells than in healthy cells. When the probe identifies cancerous cells, it triggers a fluorescent signal in those areas, while healthy tissue remains dark.

In tests conducted on mice with melanoma and breast cancer, the survival rate of mice that underwent probe-assisted surgery was double that of the mice who received regular surgery. Now that the team has registered patents for the technology, the next step is to start clinical trials with hopes of commercially marketing the probe.

Issels®: The Leader in Personally Developed Cancer Treatment

Our comprehensive cancer treatment programs incorporate a wide range of methods in order to address each patient’s individual needs. Contact us to learn more about the “Issels® Difference.”

Modified Polio Virus to be Tested In Brain Cancer Research Efforts

Issels the Premier Provider of Immuno Oncology
Issels the Premier Provider of Immuno Oncology

When it comes to your health, a virus is generally something to be avoided. In a surprising discovery, a virus that normally causes paralysis may hold promise as an immunotherapy for cancer treatment.

Can a Virus Actually Fight a Tumor?

Glioblastoma is the most common and most deadly form of brain cancer affecting adults. It gained a measure of public awareness after former Sen. Edward Kennedy and Beau Biden, son of former Vice President Joe Biden, succumbed to the disease. One year ago Sen. John McCain, already a cancer survivor, was diagnosed with glioblastoma.

Poliovirus, which causes the paralyzing disease that shares its name, infects cells in the nervous system. Based on this feature, a team of Duke University scientists decided to test a genetically modified version on patients with treatment-resistant glioblastoma.

Poliovirus and the Immune System: A Two-Pronged Attack

The researchers neutralized the virus by replacing the specific gene that causes polio with one from rhinovirus, which generally causes head colds. Once infused directly into the tumors, the newly formed virus was able to infect and kill cancer cells as well as stimulate the immune system to attack the cells.

According to team member Dr. Darell Bigner, the group’s 21 percent survival rate after three years is more than five times that of a previously treated comparison group. The researchers are planning to conduct studies combining the modified poliovirus with other immunotherapy for cancer drugs in hopes of improving the results.

Treatment for Advanced and Therapy-Resistant Cancers

Our Issels® immunotherapy for cancer programs have helped a number of patients when other treatments have failed. Contact us for more information.

Should Immunotherapy be the Last Resort for Cancer Treatment?

It's Time to Cross Out Cancer! Using Immunotherapy Treatments
It’s Time to Cross Out Cancer! Using Immunotherapy Treatments

While immunotherapy for cancer has provided an exciting new avenue for scientists, there is still much to be learned about which patients will respond, leading to a serious dilemma for doctors: when all other methods have failed, is it ethical to provide cancer patients with immunotherapy treatments on an experimental basis?

If a Little Is Good, Is a Lot Better?

You need to go back only to the 1980s and 1990s for an example of the dangers of treating patients with untested methods. Many doctors began giving women with breast cancer higher-than-usual doses of chemotherapy and radiation based solely on theory, but it turned out that the treatment was worse than the disease.

Immunotherapy for cancer drugs that have received approval, such as Opdivo and Keytruda, are restricted to a narrow range of patients. Many oncologists won’t consider immunotherapy as an option outside of its designated uses.

“Desperation Oncology”: A Last Chance

Recently, though, oncologists such as Dr. Oliver Sarter of Tulane Medical Center have begun to offer what they refer to as “desperation oncology.” The reasoning is that if a cancer patient is terminal and there’s even an infinitesimal chance that an immunotherapy drug may help, it’s worth the risk.

Not surprisingly, results have been mixed. Drugs had no effect on one patient with bladder cancer who was treated by Dr. Sarter, while another patient with metastatic prostate cancer went into immediate remission upon treatment.

Tailoring Immunotherapy for Cancer to the Patient

At Issels®, we conduct a number of tests to ensure that we design a course of treatment that’s appropriate for each patient. Contact us for more information.

Lymph Node Metastasis Uses Blood Vessel Pathways to Spread Cancer

Metastasis Uses Blood Vessel Pathways
Metastasis Uses Blood Vessel Pathways

Lymph node metastasis can have major implications for immuno oncology treatment. In a recent study, scientists examined the progression of metastatic tumor cells to learn more about how they are disseminated throughout the body.

Is Treatment of Lymph Node Metastases a Priority?

When cancer metastasizes in the lymph nodes, it’s generally a sign of an exceptionally aggressive tumor and a poor prognosis. Scientists differ on the treatment of lymph node metastases, with some experts believing it’s “clinically inconsequential” while others think they should be treated promptly to prevent distant metastases.

Results of clinical testing further complicate the issue. In one trial, removal of anything beyond the first lymph node had no benefit for patients who had received radiation and systemic therapies, while in another, lymph node treatment was found to help a subgroup of patients with breast cancer.

Tracing the Journey of Metastatic Cancer Cells

A team of researchers implanted a group of mice with cancer cells that expressed a photoconvertible protein known as Dendra2. This feature allowed scientists to photoactivate selected metastatic cells in the lymph nodes and follow their path.

Originally, metastatic cells were thought to travel by either blood vessels or the lymphatic system. In studying the affected mice, scientists determined that the metastatic cells followed a hybrid route by invading blood vessels within a lymph node, using it as a means of exit by which the cells could travel to the lungs and other organs.

Issels®: Leading the Way in Immuno Oncology for Advanced Cancers

Our comprehensive immuno oncology treatments have helped a number of patients with metastatic and recurring cancer. Contact us for more information.