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New Tao Brush Technique May Find More Female Pelvic Cancers Early

New Tao Brush Technique May Find More Female Pelvic Cancers Early
New Tao Brush Technique May Find More Female Pelvic Cancers Early

Ovarian and uterine cancers are often detected too late for effective treatment. Immuno oncology got a major boost recently with the development of an advanced Pap test that can provide early diagnosis.

Improving Early Detection of Female Pelvic Cancers

Researchers from McGill University and Johns Hopkins University teamed up to work on PapSEEK. This safe and minimally invasive test uses Pap samples from the uterus, cervix and blood to identify common genetic mutations in cancer DNA.

While the standard Pap test collects samples from the cervix, McGill professor Lucy Hopkins suggested that the team collect samples from the uterus as well to increase chances of detecting other types of cancer. They used a method called the Tao brush technique to improve the sensitivity of the test.

Going Beyond Traditional Testing

PapSEEK was tested on samples from more than 1,300 women from different hospital sites in different countries. Just over 600 of the samples were from patients with endometrial or ovarian cancer, while the others were healthy controls.

The researchers were able to detect 81 percent of endometrial cancers and 33 percent of ovarian cancers, with higher rates when the Tao brush technique was implemented. In addition, there were no false-positive results.

According to Gilbert, the Pap smear has reduced the number of cervical cancer deaths, but endometrial and ovarian cancers were going undetected. Gilbert believes that PapSEEK will be a valuable breakthrough, just as the original Pap test was.

Immuno Oncology for Late-Stage Cancers

Issels® has a proud history of helping patients achieve remission after a diagnosis of late-stage cancer. Visit our website to learn more.

Neoantigens , Dendritic Cells, and T Cells Target the Attack on Cancer

Knowing What Every Vocab Word Related to Cancer Is Important.
Knowing What Every Vocab Word Related to Cancer Is Important.

Immunotherapy cancer treatment continues to be a focus for scientists, who are excited about the number of possibilities it holds for patients. A Harvard-based research team recently conducted a study showing how neoantigens can be used to personalize treatment methods.

Neoantigens and the Immune Response

Neoantigens are tumor-specific mutated peptides that the diseased cells present on their surface. These neoantigens stimulate an immune system response by activating dendritic cells (DCs), which in turn initiate an attack on the tumor by T cells.

The challenge became how to integrate different peptides into a form that was readily acceptable to the immune system. David Mooney and his team at Harvard set out to solve the problem with the use of a vaccine delivery system.

The vaccine created by the researchers features tiny mesoporous silica rods (MSRs) coated with polyethyleneimine (PEI), which is a polymer that delivers material to cells. Once the vaccine is injected under the skin, the MSRs spontaneously form a 3-D scaffold to attract and stimulate DCs.

Fighting Recurrence of Tumors

When tested on mice, not only did the vaccine activate anti-tumor responses, it created an immune-specific memory that continued to reject tumor cells for at least six months. According to Mooney, the scaffold structure will allow for greater personalization of cancer treatment as doctors are increasingly able to predict the neoantigens present in individual tumors.

Cancer Treatments Designed for Each Patient

Issels® has long been in the forefront of using personally tailored cancer treatment, including dendritic cell vaccines, to meet a patient’s specific needs. Contact us for more information about our non-toxic, integrative treatment programs.

Take Care with Antibiotics Now to Prevent Cancer Treatment Hampering Reactions

In Order To Achieve the Best Cancer Care Possible, You Must First Make Sure Your Body is Open to These Options to Its Best Ability.
In Order To Achieve the Best Cancer Care Possible, You Must First Make Sure Your Body is Open to These Options to Its Best Ability.

Doctors always take care when prescribing combinations of drugs due to possible negative interactions. It’s not surprising that mounting evidence indicates the complex balance of targeted cancer treatment can be upset by use of antibiotics.

Disrupting the Body’s Natural Defenses

According to results of a study conducted at the Georgia Cancer Center, this problem stems from the effect of antibiotics on gut microbiota, the network of bacteria, viruses and fungi that resides in the digestive tract. These “good” germs aid with digestion and protect our system from “bad” germs.

In the process of killing off microorganisms that cause infections, antibiotics also destroy large amounts of gut bacteria. As a result, patients on a course of antibiotics often experience nausea, vomiting, diarrhea and other gastrointestinal symptoms.

The Connection Between Gut Bacteria and Cancer Treatment

Dr. Gang Zhou, corresponding author of the study, explained that certain bacteria in the microbiota are necessary to activate the T-cells involved in cancer treatment known as adoptive T-cell therapy. A newer form of treatment called CAR T-cell therapy appears to be resistant to the antibiotic effect because it works on its own, with little reliance on the immune system.

Co-author Dr. Locke Bryan pointed out that antibiotics are often used in conjunction with chemotherapy. This traditional cancer treatment lowers white blood cell counts to the point where there’s no defense against bacteria, and an infection can be lethal to an already weakened immune system.

Individualized Treatment Plans for Specific Needs

Our personally tailored immunobiologic core treatments are designed to remove or repair factors that inhibit the body’s natural defense mechanisms. Contact us for more information.

“Feed” Your Battle Against Breast Cancer with These Food Tips

Diet Tips for Breast Cancer Patients
Diet Tips for Breast Cancer Patients

Is there an ideal diet to aid in breast cancer treatment? While there is no ‘best diet’ for those undergoing treatment, to reduce the risks of treatment and support your body, nutritional science conducted by the University of Hawaii Cancer Center points to ways that modifying diet may help.

Taking a ‘Bite’ Out of Risks

In terms of breast cancer treatment and prevention, research shows this hormonally-driven disease is strongly affected by obesity. However treatment time is NOT the time for weight loss. Instead, a shift to the development of healthful habits, including a balanced diet that promotes overall health, is ideal.

Foods that Feed the Battle

A diet of fresh veggies, plant-based proteins, and high-fiber foods – foods packed with phytochemicals, antioxidants, flavonoids, isoflavones, and other super-food, cancer-fighting properties – is ideal. Limiting alcohol intake is also advisable, as excessive intake is linked to cancer risk.

What’s on the Menu?

– Cruciferous veggies like broccoli, Brussel sprouts, and cauliflower.
– Plant-based proteins, including soy, beans, nuts and seeds.
– Other lean proteins that help boost immunity and retain muscle mass, such as poultry, fish, and eggs.
– High-fiber fruits, veggies, and grains like rice and quinoa that keep appetite (and cholesterol) in check.

Planning for Success

Planning shopping and meals on ‘good days’ can help make dietary changes and adequate nutrition easier. Form a monthly/weekly meal plan, ‘batch cooking’ large hearty stews or casseroles that can be easily packed into smaller portions for easy reheating when you’re under-the-weather. Aim for 5-6 smaller meals/day.

Looking for the ‘magic pill’ for breast cancer treatment? Ensure a better outcome with the help of Issels® today.

New Imaging System Identifies If a Breast Cancer Will Respond Favorably to Chemotherapy

New Imaging System Identifies If a Breast Cancer Will Respond Favorably to Chemotherapy
New Imaging System Identifies If a Breast Cancer Will Respond Favorably to Chemotherapy

When it comes to fighting tumors, effective cancer treatment is only part of the equation. Researchers are also seeking ways to determine which patients will be more receptive to a particular course of treatment. A recent study offers encouraging results for a method of predicting breast cancer response to chemotherapy.

Predicting Chemotherapy Response in Breast Cancer Patients

Women newly diagnosed with breast cancer that is invasive but operable frequently undergo neoadjuvant chemotherapy beginning five to six months before surgery. Chances of recurrence are reduced in patients whose cancer cells are completely eliminated by the chemotherapy.

According to Dr. Dawn Hershman, co-leader of the study conducted at Columbia University in NYC, determining which patients are likely to achieve a favorable response makes a significant difference in cancer treatment. If their chances of positive response are low, adjustments can be made for a more effective treatment.

Reading the Clues in 3D Imaging

Based on the idea that chemotherapy affects a tumor’s vascular network, the research team set out to determine if imaging could be used to detect these changes. Blood absorbs light, so the scientists used a system incorporating red and near-infrared lighting.

Armed with 3D images of both breasts, researchers studied the ways in which blood interacted with the tumors. In a group of 34 patients, blood outflow accurately identified 92.3 percent of responders, while increase in blood concentration identified non-responders in 90.5 percent.

Advanced Stage Cancer Treatment at Issels®

Patients with advanced and therapy-resistant tumors have turned to Issels® for non-toxic, personalized treatment programs. Visit our website to read and hear testimonials from our patients who have achieved long-term remission.

New Swedish Study Shows Selenium-containing Enzyme May Combat Cancer

New Swedish Study Shows Selenium-containing Enzyme May Combat Cancer
New Swedish Study Shows Selenium-containing Enzyme May Combat Cancer

One of the challenges of cancer treatment research is distinguishing between effects on healthy cells and tumor cells. Scientists in Sweden have been focusing on inhibiting a chemical that is beneficial to human health but also promotes the growth of cancer.

The Connection Between Selenium Intake and Cancer

Selenium is a chemical element with a Recommended Dietary Allowance determined by the Food and Drug Administration. An enzyme known as TrxR1 contains selenium, which supports cell growth and protects them from oxidative stress. Raised levels of TrxR1 are also associated with occurrences of cancer, although the causes are not yet understood.

While TrxR1 inhibitors are available, a research team at Karolinska Institutet in Sweden analyzed nearly 400,000 molecules looking for new and more specific versions. Their search turned up three molecules, which the scientists used to treat more than 60 types of cancer cells under laboratory conditions.

Treating Cancer While Sparing Healthy Cells

Healthy cells proved to be far less vulnerable to the TrxR1 inhibitors. Team leader Professor Elias Arner explained that the difference may be caused by cancer cells having a greater vulnerability to oxidative stress than normal cells.

Cisplatin, melfalan and some of the other cancer drugs currently in use contain TrxR1 inhibitors, although not the ones that were the focus of this study. It’s unclear whether the TrxR1 inhibition factor plays a role in the effectiveness of the drugs, but researchers will continue investigating these new molecules as cancer treatments.

Cancer Treatment Designed for Your Needs

Issels® has a successful history of creating individual cancer treatment programs addressing a patient’s particular needs. Contact us for more information.