Tag Archives: Advances In Cancer Treatment

Will CRISPR Gene Editing Play a New Role in Cancer Treatment?

New Research Is Unlocking the Mystery of Cancer
New Research Is Unlocking the Mystery of Cancer

As science makes connections between DNA mutations and cancer, gene-targeted therapies have become a valuable way to make cancer treatment more effective. Now researchers are pondering how advanced genome editing technology might impact the future of cancer research and treatment.

Solving the Puzzle of DNA

All biological lifeforms are composed of three primary substances. DNA, the building block of genes, uses RNA as a messenger to control proteins, which are the cellular “worker bees.” RNA and proteins can be targeted with drugs, medicines and other treatments, but DNA is more complicated.

CRISPR is a process that lets scientists actually manipulate and make changes to genetic material in cells. In theory, CRISPR could be used to “edit” diseases such as cancer right out of patients.

Can Genetic Editing Improve Cancer Treatment?

Finding the precise genes that drive cancer development can be like looking for a needle in a haystack. With the help of CRISPR, researchers can replace normal genes with cancer-causing ones to get a better picture of how the mutations work and thereby create more effective treatment solutions.

According to Dr. Irene Chong, a clinical scientist at the Institute of Cancer Research in London, the precision of CRISPR holds possible ramifications for future cancer treatment. Doctors may eventually be able to target and correct genetic mutations that cause a predisposition to cancer.

Gene-Targeted Therapies at Issels®

Issels® has long been a leader in the use of gene-targeted therapies that reduce the risk to healthy cells often found in traditional cancer treatments such as chemotherapy. Contact us for more information about cancer vaccines, NK cells and other state-of-the-art treatments at Issels®.

Molecularly Targeted Therapy Emerges As Another Possible Cancer Treatment

Molecularly Targeted Therapy Emerges As Another Possible Cancer Treatment
Molecularly Targeted Therapy Emerges As Another Possible Cancer Treatment

The problem with traditional cancer treatments is that they attack healthy cells along with diseased cells, which results in serious side effects such as fatigue and hair loss. Doctors are encouraged by the success of a new cancer treatment that zeroes in on the cancer cells.

The “Next Revolution in Cancer Therapy”

Molecularly targeted therapy is being hailed as the next big step in cancer treatment. These new drugs are designed at the molecular level to attack the diseased cells of a specific type of cancer. In addition, they can identify specific molecules that are part of specific cancers.

The drugs are created by a process that is the reverse of how most cancer drugs are developed. Scientists identify an abnormal molecule that’s unique to a particular type of cancer, then design a drug that shuts down its activity.

Gleevec: Paving the Way

Novartis Pharmaceuticals has developed Gleevec, also known as STI571, which is leading the way for molecularly targeted therapy. Gleevec is used for chronic myeloid leukemia, or CML, which is a rare form of the disease characterized by excessive production of white blood cells.

Researchers discovered that Gleevec is also effective against GIST, a rare gastrointestinal cancer. GIST features a unique enzyme related to the original target enzyme in CML.

State-of-the-Art Cancer Treatment at Issels®

Gene-targeted therapies, including Gleevec, Tamoxifen and Avastin, are a significant part of our personalized treatment programs. Issels® also uses non-toxic immunotherapy treatments that boost the immune system’s ability to target tumor cells.

Contact us today for more information about our decades of success in helping patients achieve long-term remission.

Cancer News: Cancer Can Metastasize Without Involvement of the Lymph System

Metastatic cancer, where tumors spread from the original site to other parts of the body, presents a significant challenge for cancer treatment. Current research is causing scientists to rethink the conventional model of metastasis.

The Role of Lymph Nodes in Cancer Metastasis

A team of researchers led by Dr. Rakesh Jain of Massachusetts General Hospital studied 213 tissue samples from 17 patients diagnosed with colorectal cancer. The focus was on relationships between cells from the primary tumor, lymph nodes and remote sites of metastasis.

The scientists were surprised to discover that only 35 percent of the patients presented the traditional path of cancer moving via lymph nodes to more distant sites. In these cases, cancer cells from both metastases matched cell types in the original tumor.

In the other 65 percent of patients, both metastases matched different cells within the primary tumor, indicating separate origins. These results demonstrate that cancer may metastasize without involvement of lymph nodes, contradicting previously-held beliefs.

Applications for Future Cancer Treatment

According to Dr. Jain, lymph node metastases were generally considered forerunners of more distant metastases. Scientists were therefore puzzled why complete surgical removal of lymph nodes didn’t always improve survival rates.

Dr. Jain went on to explain that the typing assay his team developed can be a valuable way to analyze cancer’s path in certain patients. The information can then be used for better clinical management of metastatic cancer treatment.

Individualized Treatment for Patients at All Stages of Cancer

Issels® has an impressive track record of successfully treating cancer patients at all stages, including stage IV or metastatic cancer. Contact us for more information.

Gold Nano Particles May Boost Lung Cancer Treatment

Gold Nano-particles Can be Introduced into the Bloodstream to Help Fight Cancer.
Gold Nano-particles Can be Introduced into the Bloodstream to Help Fight Cancer.

Gold may have a value that goes well beyond financial gain. Researchers have discovered that the shiny element can enhance the effectiveness of drugs used to treat lung cancer.

Cancer Treatment as Good as Gold

Testing was conducted at the University of Edinburgh, where Scientists took nanoparticles, which are microscopic particles of gold, and encased them in a chemical device. The object was then used on zebrafish to successfully accelerate their chemical reactions.

Dr. Asier Unciti-Broceta from Cancer Research U.K.’s Edinburgh center participated in the study. He explained that the team’s goal was to find a way to reduce side effects of current chemotherapy methods.

Lessening the Side Effects of Traditional Cancer Treatment

Side effects of cancer treatment are usually the result of drugs attacking healthy cells as well as diseased ones. According to Dr. Unciti-Broceta, their findings indicate that gold could possibly be used to safely release drugs inside tumors.

Immunotherapy for cancer is effective because it helps the immune system’s ability to target cancer cells while sparing healthy tissue. Researchers are continuing tests with nanoparticles in the hopes of applying a similar method with humans.

Dr. Aine McCarthy, also of Cancer Research U.K., expressed optimism that incorporating gold in immunotherapy for cancer could improve the outlook for hard-to-treat cancers such as brain tumors.

Issels®: The Gold Standard of Immunotherapy for Cancer

Our integrative cancer treatment programs are personally tailored for each patient to include methods that complement each other for maximum effectiveness. Contact us today to learn more about our distinguished history of treating patients with all forms of cancer.

Genetic Advances Made in Prostate Cancer Identification

Prostate cancer affects approximately 15 percent of males in their lifetime, and is second only to skin cancer. Recent identification of an overactive gene that accelerates prostate cancer could lead to development of a more effective treatment.

Prostate Cancer Evolves Beyond Drugs

Most prostate tumors are caused by a form of cancer called adenocarcinoma. In advanced stages, adenocarcinoma is treated with drugs that block androgens, the male hormones that fuel the tumor. Unfortunately, the tumors have evolved into a more aggressive, androgen-resistant form called neuroendocrine prostate cancer.

Prostate Cancer Identification
Prostate Cancer Identification

A cross-disciplinary team supported by the Prostate Cancer Foundation discovered a gene known as N-Myc that appears to be the driver behind the change to the more aggressive form. While N-Myc is not usually found in prostate cancer, it has been known to occur in other forms such as neuroblastoma, a rare cancer of the nervous system found in children.

A Pathway to New Treatment Methods

When N-Myc goes into overdrive, it teams up with a protein called EZH2 to block the tumor’s androgen signaling and “flips the switch” on the molecular program that leads to the more aggressive neuroendocrine form. Dr. Jonathan W. Simons, president and CEO of the Prostate Cancer Foundation, calls this a “game-changing” discovery that can enable development of more successful treatments.

Personalized, Non-Toxic Treatments for Prostate Cancer

Issels® offers a wide range of Immunotherapy for Cancer protocols, including vaccines and NK cells that have been used to treat patients with prostate cancer, melanoma, leukemia and all other forms. Contact us today to find out how Immunotherapy for Cancer at Issels® can help you or your loved one.

Promising New Treatments Use Molecular Cancer Classifications for Melanoma

Cancer Treatment in Tijuana
Preventing Melanoma

In a groundbreaking effort that could lead to improved strategies even for stage four melanoma treatment, researchers have gathered national data to better determine cancer risk of four major molecular subtypes of cancer. What does this mean for your cancer treatment efforts? Issels® wants you to know.

Improved classification of data = better treatment.
Broken down by age, race/ethnicity, poverty level, and other factors, the data gathered will help researchers more accurately determine the degree of risk, and cancer patients better understand health implications based on their breast cancer subtype, as each of the four major molecular subtypes responds differently to treatment and has varying survival rates.

More access = better treatment.
Also improving strategies for stage four melanoma treatment, the data gathered has been recorded by cancer registries nationwide, making widely available medically important information to guide therapeutic strategies for these cancer subtypes.

Faster identification = better treatment.
The new diagnostic categories identified by researchers will further support the prevention and treatment of multiple types of cancer, as well as monitor their incidence and outcomes, providing further necessary data for the use in stage four melanoma treatment.

Promising findings = a better future for you.
The findings, as well as the statistical analysis of the most common types of cancer, were reported in “The Annual Report to the Nation on the Status of Cancer, 1975-2011,” which also confirmed encouraging trends in cancer mortality among men, women, and children alike, reflecting the progress made over the years in cancer prevention, early detection, and treatment.

Struggling with stage four melanoma treatment? Issels® help you on the path to recovery. Contact us today.