Tag Archives: Cancer Immunotherapy

The Connection Between Tumors and Blood Vessels

Stop Cancer
Stop Cancer

The medical community has long believed that cancer cells support their growth by generating blood vessels. A recent study suggests that blood vessels may actually begin the cycle of tumor development.

“Hijacking” Blood Vessels for Tumor Development

According to cancer biologist Dr. Lan Ko, one of the authors of the study, the team found evidence that blood vessels can create tumors. In turn, the cancer cells then produce blood vessels to further sustain their growth.

Researchers focused on GT198, a gene generally found in low levels within the body. It has a natural ability to repair DNA and regulate stem cells, but in mutated form it creates cancer cells.

Pericytes, found in the outer layer of blood vessels, resemble stem cells in the way they can form different types of tissue. During the study, researchers found abnormally high levels of GT198 in pericytes supporting a number of human tumors.

Even more surprising was that the GT198 was located in the pericytes’ cytoplasm instead of the nucleus. This enabled malignant pericytes to multiply into cancer cells and detach from blood vessels to promote spread of the tumors.

Application for Cancer Treatment

As Dr. Ko explained, these results indicate that GT198 is a viable target for immunotherapy for cancer treatments. Further testing will explore use of existing cancer drugs and development of new ones.

Issels® Leads the Way in Immunotherapy for Cancer

While immunotherapy for cancer has become a hot topic among scientists, Issels® has been successfully using our integrative, non-toxic treatments for decades. Contact us for more information about cancer vaccines and our other individually tailored programs.

What is Recurrent Cancer – What Do I Need to Know?

What Do I Need to Know?
What Do I Need to Know?

Have you ever heard stories about patients undergoing immunotherapy for cancer and experiencing no recurrence? Here’s what you need to know about recurrent cancer and what it means in terms of your overall health.

When Cancer Comes Back

Recurrence refers to cancer that returns after treatment has been completed. It originates with cancer cells that remained after the first course of treatment but were too small to show up in post-treatment testing.

Recurrent cancer is the same form as the original tumor, as opposed to a new type of cancer that may develop in patients who have a history of tumors. The latter is known as second primary cancer.

Types of Recurrent Cancer

Cancer recurs in three different ways:

• Local recurrence is in the same general area as the original tumor.

• Regional recurrence describes cancer that has grown into lymph nodes or other tissues near the original cancer.

• Distant recurrence is when cancer has spread to organs or other tissues far from the original site.

Another term that describes distant recurrence is metastatic cancer. Regardless of where the cancer has spread, it’s still the same type as the original tumor.

Testing and Treatment

Your doctor will likely repeat many of the same tests that resulted in the first diagnosis. These tests provide information to help determine the appropriate course of treatment.

Effective Non-Toxic Immunotherapy for Cancer at Issels®

The personally tailored immunotherapy for cancer treatments at Issels® are designed to boost your own immune system’s ability to recognize and destroy cancer cells. Contact us today to learn how our programs have helped patients achieve long-term remission.

Identification of Specific T Cell Presence May Boost Lung Cancer Immunotherapy Treatment Success

New Cancer Research on T Cells
New Cancer Research on T-Cells for Lung Cancer

While immunotherapy for cancer has been a breakthrough for more effective treatment, the challenge is determining which patients will receive the most benefit. A joint US-UK study recently made a discovery that could help solve the problem for lung cancer patients.

Fighting Lung Cancer with T-Cells

The study was conducted by researchers from the University of Southampton and La Jolla (CA) Institute for Allergy and Immunology. The team focused on lung cancer, which is the most common cause of cancer deaths in both countries.

Findings showed that lung cancer patients with larger quantities of tissue-resident memory T-cells in their tumors had a 34 percent greater chance of survival. In addition to serving as protection for the patient, these T-cells produce molecules that attack and destroy cancer cells.

This process corresponds nicely with immunotherapy for cancer, which works by boosting the body’s own natural defense mechanisms against disease. Testing lung cancer patients for levels of tissue-resident memory T-cells can provide an indication of the likelihood that they will benefit from immunotherapy.

Understanding the Role of the Immune System and Immunotherapy

Dr. Justine Alford of Cancer Research UK spoke about the importance of such studies to gain insight into the interaction between cancer cells, the immune system and immunotherapy. She adds that research could lead to more personalized treatments for patients with lung cancer and other forms that are difficult to treat.

Personalized Immunotherapy for Cancer at Issels®

For decades, Issels® has been creating personalized immunotherapy programs for patients based on their own unique needs. Contact us to learn more about our testing and treatment methods.

Precision Medicine May Allow Specialized Treatment Targeting

Precision Medicine May Allow Specialized Treatment Targeting
Precision Medicine May Allow Specialized Treatment Targeting

The rise of immunotherapy and other advancements in cancer treatment have put a positive light on the longstanding fight against the disease. Unfortunately, more aggressive forms of cancer such as lung, pancreatic and brain continue to resist even the most sophisticated therapies.

Not All Tumors Are Created Equal

Renewed attention to this issue arose during recent reports of Arizona Sen. John McCain’s diagnosis of glioblastoma, a particularly stubborn form of brain cancer. Despite extensive research and testing of innumerable treatment modalities, little progress has been made against glioblastoma.

Researchers have come to realize that a paradigm shift is needed in their approach to these hard-to-treat forms of cancer that don’t “follow the rules” of other types. It’s not enough to simply apply methods used to treat tumors with similar mutations.

Targeting Hard-to-Treat Tumors with Precision Medicine

Precision medicine can help determine why these stubborn cancers have failed to respond to previous treatments. For example, the Defeat GBM Research Collaborative is systematically identifying targets for cancer treatment as well as possible areas of resistance.

The blood-brain barrier is a literal roadblock in treating glioblastoma. This network, located within small blood vessels inside the brain, keeps dangerous toxins and chemicals out, but it also repels drugs designed to attack cancer cells.

Cancer Treatment: One Size Does NOT Fit All

At Issels®, we understand that what works with one patient is not necessarily going to work with another. We use specialized testing methods to create an individual treatment program based on your personal situation. Contact us to learn more about cancer vaccines, NK cells and other non-toxic immunotherapy protocols.

FDA Quickly Approves New One-of-a-Kind Cancer Treatment

There is New Hope for Cancer Patients.
There is New Hope for Cancer Patients.

Researchers have made a number of significant breakthroughs in cancer treatment, but a recent development has the healthcare community particularly excited. The Food and Drug Administration (FDA) has approved a drug that treats tumors based on a genetic abnormality.

Keytruda: A Landmark in Immunotherapy for Cancer

Pembrolizumab, marketed under the trade name Keytruda, was tested on a trial group of 86 patients. The results were remarkable: 66 patients saw their tumors shrink and stabilize, while the tumors in 18 of them disappeared with no recurrence.

What’s different about Keytruda? It’s the first drug that attacks tumors from a shared genetic profile rather than the actual location of the tumor. A prospective patient first undergoes testing to determine whether he or she is a genetic match for the mutations targeted by Keytruda.

Current and Future Possibilities

At present, Keytruda is approved for treating only select forms of advanced bladder, lung and melanoma tumors. The drug will be effective for approximately four percent of cancer patients, which still equates to tens of thousands of people.

Scientists are encouraged by the possibility of further treatment methods tailored to a patient’s specific genetic profile. This ability would greatly enhance development of more accurate targeting and treatment.

Advanced Immunotherapy for Cancer Treatment from Issels®

Issels® uses genomic testing to determine a patient’s individual treatment needs. We then use the information to tailor a personalized immunotherapy for cancer program including methods such as vaccines and NK cells.

We have helped patients with all forms of cancer achieve long-term remission. Contact us to learn more about why the Issels® difference may be right for you.

It’s UV Safety Awareness Month – Protect Your Skin from Melanoma Cancer

Keep Your Skin Safe This Summer.
Keep Your Skin Safe This Summer.

The sun’s rays can give you a nice golden glow, but they can also increase your risk for melanoma or skin cancer. With summer vacations in full swing, July has been designated as UV Safety Awareness Month to promote good skin care habits.

Tips to Protect Your Skin from Sun Exposure

  • Use a broad-spectrum waterproof sunscreen that protects against both UVA and UVB rays, which have longer wavelengths to penetrate the ozone layer. Look for a sunscreen with a minimum sun protection factor (SPF) of 15 unless you’ll be outdoors for an extended period of time, in which case you should use SPF 30 or higher.
  • Apply one ounce of sunscreen to all exposed areas approximately 30 minutes before heading outside. Reapply every two hours and more frequently if you’re spending time in the water.
  • Wear a broad-brimmed hat to protect your face and scalp along with UV-blocking sunglasses.
  • Avoid the sun during peak hours between noon and 4 PM. Stay in the shade whenever possible.
  • Sunburn causes skin damage that can lead to the development of melanoma. Even if you’ve taken precautions, seek cover if your skin starts to become pink and tender.

Exposure to the sun can also hasten the development of wrinkles, leathery skin, eye problems and other signs of aging, which is another reason to use protection.

Fighting Melanoma with Immunotherapy for Cancer

At Issels®, our integrative immunotherapy for cancer treatments have helped patients diagnosed with melanoma, leukemia, breast cancer and all other forms. Contact us to learn more about why immunotherapy for cancer may be right for you.