Tag Archives: Cancer Treatment

Breast Cancer Patients Treated with Combination Drugs Suffer More Side Effects

New Research for Breast Cancer Studies Genes
New Research for Breast Cancer Studies Genes

One of the concerns with traditional cancer treatment is the range and severity of potential side effects that may occur. Based on the results of a recent study, patients with advanced breast cancer who are treated with a certain combination of drugs are at greater risk for serious side effects.

Fighting Cancer on Two Fronts

Some breast cancers are classified as “hormone receptor-positive.” Signals from hormones such as estrogen and progesterone reach receptors in the cancer cells, triggering further growth. Patients are commonly treated with a receptor blocker such as tamoxifen in conjunction with drugs that specifically target molecules involved in cancer cell development.

Previous research indicated that this combination therapy enabled patients to live longer without progression of the tumors. The missing piece of the puzzle was the extent to which treatment could cause side effects.

Evaluating Side Effects of Combination Therapies

A study conducted by an international research team found that patients with combination therapy were more susceptible to side effects such as fatigue, diarrhea and hyperglycemia. The degree of risk varied based on the particular drugs involved.

Scientists plan to use these results to design courses of treatment that are less likely to produce side effects. In the meantime, since these therapies do have benefits, doctors will have more information to use in prescribing and managing combination drug treatments.

Issels® Leads the Way with Non-Toxic Cancer Treatment

Personalized cancer treatment at Issels® uses a patient’s own immune cells, reducing the risk of of debilitating side effects. Contact us to learn more about our cancer vaccines and other innovative treatment programs.

Drug Resistant Cancer Cells Appear to Share a Similar Weakness

Medical Research Has Validated that Immunotherapy Works to Fight Cancer
Medical Research Has Validated that Immunotherapy Works to Fight Cancer

Cancer researchers at UC San Francisco have discovered a common gene vulnerability in certain treatment-resistant cancers. This is yet another promising advancement that could lead to better treatment of existing cancers and a new approach to preventing cancer recurrences.

Visit Issels® for more information on how combining traditional cancer treatments with integrative immunotherapy can reduce the incidence of relapse from 13 to 50 percent.

Understanding drug-resistant cancer cells

For many years, oncologists thought the drug resistance of cancer cells evolved genetically. Doctors thought a few of the cells survived cancer treatment because they had or somehow developed gene mutations to withstand traditional treatments. These remaining cells would then lead to a recurrence of cancer.

In 2010, researchers working at the Massachusetts General Hospital Cancer Center found that some cancer cells may be able to avoid the effects of treatment without any genetic mutations. These small clumps of cells are called “persister cells” and they go into a dormant state, allowing them to survive cancer drugs. The cells awaken later and lead to new cancer growth.

Exploiting persister cell weaknesses

Matthew Hangauer, PhD led the UC San Francisco study. He said persister cancer cells have a mesenchymal-like gene expression signature and rely on the enzyme glutathione peroxidase 4 (GPX4) to survive treatment. Lab tests show that blocking GPX4 can kill the persister cells found in many different cancer types. Researchers hope to soon validate their findings with human patients.

The Issels® non-toxic cancer treatment

Our caring and knowledgeable experts have helped many patients achieve long-term remission from cancer by using personalized immunotherapy treatment protocols. Contact us for more information.

Gut Bacteria Appears to Influence Whether or Not Cancer Tumors Will Shrink During Cancer Treatment

New Cancer Research Is Improving Treatment
New Cancer Research Is Improving Treatment

Bacteria is generally considered to be the cause of disease and infection, but many varieties have beneficial properties. Scientists are discovering that “good” bacteria living inside of us can have positive implications for cancer treatment.

How Can Bacteria Be “Good?”

The microbiome is a collection of microscopic organisms found inside our bodies, primarily in the gut. These organisms play a role in the digestive process and help to regulate the immune system.

Researchers in France and the United States conducted separate studies involving the microbiome of cancer patients. All participants were receiving immunotherapy treatment, which boosts the ability of the immune system to fight cancer cells.

The Relationship Between Gut Bacteria and Cancer Treatment

The team at the Gustave Roussy Cancer Campus in Paris studied 249 patients with lung or kidney cancer.

– Participants who had taken antibiotics, which disturb the microbiome, were more likely to experience tumor growth, even during treatment.

– A bacteria species known as A. muciniphila was found in two-thirds of patients who responded to immunotherapy, as opposed to only one-third of those who did not.

At the University of Texas MD Anderson Cancer Center, a team analyzed the microbiome of 112 patients with advanced melanoma.

– Patients who responded to cancer treatment were found to have a more rich and varied microbiome than those who didn’t.

– The composition of the microbiome also appeared to be significant, as higher levels of certain bacteria were associated with positive responses while others had negative impacts.

Innovative Cancer Treatment at Issels®

Our immunotherapy programs focus on cancer cells as well as the internal environment that supports them. Contact us for more information.

New Treatment Breaches Blood Barrier for Treatment of Glioblastoma

New Research is Helping to Understand Brain Cancer
New Research is Helping to Understand Brain Cancer

Brain tumors are notoriously resistant to most types of cancer treatment. Scientists have recently discovered that a drug that targets one form of cancer may also have applications for treating brain tumors.

Why Brain Tumors Are Difficult to Treat

Despite improvement in overall cancer survival rates, the numbers for brain cancer remain low. Scientists attribute this to the blood brain barrier, which is a natural filter that prevents drugs from reaching the tumors.

In a study funded by Cancer Research UK, scientists recruited 48 patients with glioblastoma, a particularly stubborn form of brain cancer, that had returned after treatment. The patients were given olaparib, a PARP inhibitor used to treat ovarian cancer, in conjunction with temozolomide, a chemotherapy drug.

After treatment, the research team examined tumor cells and found that the drug had penetrated the core of the tumor as well as cancer cells in surrounding areas. The results were significant because surgery is not possible for this form of tumor, so cancer treatment options are limited.

New Hope for Brain Tumor Treatment

According to lead researcher Professor Anthony Chalmers, glioblastoma disturbs the blood brain barrier, allowing olaparib to reach the tumor cells. Chalmers believes that scientists will be able to build on the results of the study to improve the effectiveness of current treatments.

Professor Susan Short of the National Cancer Research Institute adds that the study shows the potential of PARP inhibitors to treat a wide range of cancer types.

Cancer Treatment for Therapy-Resistant Cancers

Issels® has helped numerous patients with stage IV cancer achieve long-term remission. Contact us for details about our non-toxic cancer immunotherapy programs.

Colon Cancer and Crohns Disease Share a Link Between Inflammation and a Cellular Process

New Research Is Unlocking the Mystery of Cancer
New Research Is Unlocking the Mystery of Cancer

Here at Issels®, it’s always exciting when we learn of new breakthroughs in cancer treatment. Research that was done by the University of Warwick shows that colon cancer (among other gut-related illnesses) could be better treated, or even prevented.

Understanding the Gut Process

Science has uncovered a lot of new information regarding the role of the gut in maintaining good health. For example, the process of autophagy triggers cells to break down damaging materials in the gut. These materials are then eliminated or re-used within the body. When this process malfunctions, it can lead to chronic diseases that impact your health. Inflammation is to blame, leading to colon cancer, Crohn’s disease, and other serious diseases.

Avoiding and Treating Colon Cancer

The foods we eat play a major role in maintaining good gut health. There are several that can activate autophagy, even when it is currently in a dysfunctional state. These foods include:

– Pomegranates

– Mushrooms

– Soybeans

– Green peas

– Red grapes

– Pears

This research has shown that the human body doesn’t always have the proper mix of amino acids necessary to keep autophagy in a functional state all of the time. However, more research is needed to better understand this important process. This may lead scientists to discover new forms of cancer treatment, perhaps even in the near future. So far, they’ve found that the addition of a protein called Kenny can be added, which includes the correct amino acids profile.

Immunotherapy as Cancer Treatment

Here at Issels®, we’re always looking for advancements in immunotherapy for treating cancer. If you’ve recently been diagnosed, please contact us today. We can help with recovery.

Focusing on a Cancer’s Host Tissue May Bring a Prognosis into Better Focus

State of the Art Treatment with Cancer Immunotherapy
State of the Art Treatment with Cancer Immunotherapy

Thanks to innovations in testing methods and proactive awareness campaigns, doctors are able to diagnose cancer earlier then ever, increasing the chances of successful cancer immunotherapy. The second part of the equation, predicting the degree of malignancy, is a puzzle that remains to be solved.

When Is a Patient Truly Free of Cancer?

After treatment, a patient who shows no signs of cancer cells is classified as “no evidence of disease.” While the patient may display no visible tumors, doctors have no way of knowing if the cells have metastasized to other areas of the body where they may later resurface.

Chemotherapy and other treatments are often prescribed to decrease the chance of metastasis. Doctors tend to err on the side of caution, assuming that all patients are vulnerable, so many endure grueling rounds of treatment that end up being unnecessary.

“Focus on the Soil, Not the Seed”

For the most part, researchers have concentrated on unraveling the mysteries of cancer cells themselves to understand how they grow and spread. In keeping with that approach, scientists believed that metastasis was caused by cells spreading outward from their original location.

Based on that theory, all cancer patients would be expected to have metastasis. Many researchers are now shifting to a view that the spread of cancer cells is caused by a pathological relationship between the diseased cells and the host environment.

State-of-the-Art Cancer Immunotherapy from Issels®

Cancer immunotherapy at Issels® is directed at the cancer cells along with the underlying causes for the development of tumors. Contact us to learn more about how Issels® has helped patients achieve long-term remission.