Tag Archives: Cancer Vaccines

Swiss Group Studies Dendritic Cell Vaccines with Artificial Receptors

New Cancer Research Is Improving Treatment
New Cancer Research Is Improving Treatment

One of the challenges doctors face with cancer treatment is designing a program to meet a patient’s unique needs. Immunotherapy for cancer is helping to provide solutions to this problem, such as recent improvements to dendritic cell vaccines.

Immunotherapy: Priming the Body’s Immune System

While the body’s immune system is extremely capable when it comes to fighting viruses, bacteria and other invaders, cancer cells often demonstrate a remarkable ability to evade detection. Immunotherapy works by enhancing the immune system’s power to target and destroy cancer cells.

Dendritic cells are one of the immune system’s “messengers” that present antigens to killer T-cells for destruction. Researchers in Switzerland began looking for a way to improve the effectiveness of dendritic cell vaccines.

Helping the Immune System Recognize Cancer Cells

Prof. Michele De Palma and his team created artificial receptors known as EVIRs, which are inserted in dendritic cells extracted from a patient. Once reintroduced into the patient’s system, the EVIRs are engineered to recognize exosomes that transport molecules between cells, sometimes assisting in the spread of cancer.

As EVIRs capture exosomes, it allows dendritic cells to present antigens on their outer surface, simplifying recognition and attack by killer T-cells. De Palma and his team have dubbed this phenomenon “cross-dressing,” and they’re hoping that the process will improve the specificity of cancer treatment.

Issels®: A Successful Legacy of Immunotherapy for Cancer

At Issels®, we are exclusively focused on immunotherapy for cancer with patients who have advanced or therapy-resistant cancers. Contact us to learn more about our dendritic cell vaccines and other non-toxic, personally tailored immunotherapy treatment programs.

Personalized Dendritic Cell Vaccines As Effective Immunotherapy Make the News

Sharing the Opinions of the Future
Sharing the Opinions of the Future

One of the benefits of immunotherapy for cancer is that treatments can often be tailored to address a patient’s individual needs. Scientists in Switzerland have now developed a method of modifying dendritic cell vaccines that makes them easier to personalize.

Aiding the Body’s Own Immune Response

Dendritic cell vaccines are normally created by force-feeding dendritic cells with tumor antigens. Scientists at the Swiss Institute for Experimental Cancer Research have developed a modification that allows dendritic cells to acquire antigens from a patient’s tumor.

Prof. Michele De Palma, winner of the 2017 Swiss Cancer League award, led the team of researchers in creating an extracellular vesicle (EV)-internalizing receptor, referred to as EVIR. The EVIR has been optimized to enhance dendritic cells and their ability to selectively uptake cancer cell-derived EVs.

Antigen-laden exosomes and other extracellular vesicles are released by tumors in sizable quantities. The EVIR helps dendritic cells target the exosomes more precisely and present them to killer T-cells for a more efficient immune response.

Streamlining the Job of Dendritic Cells

De Palma explained the phenomenon of cross-dressing, in which dendritic cells display the acquired antigens directly on their surface. The process simplifies the immune response by eliminating the need for more complex interactions within the dendritic cell itself.

Dendritic Cell Vaccines and Immunotherapy for Cancer at Issels®

Dendritic cell vaccines are only one of the non-toxic cancer treatments available at Issels®. Our individually developed programs are created to maximize the ability of your own immune system to fight cancer.

Contact us to learn more about why Issels® has long been a groundbreaking leader in immunotherapy for cancer.

Issels and the Dendritic Cell Vaccine for Cancer

It's Time to Cross Out Cancer!
It’s Time to Cross Out Cancer!

For decades, Issels® has been a leader in non-toxic immunotherapy for cancer treatments. The dendritic cell vaccine is one of the most potent weapons in our cancer-fighting arsenal, succeeding in many late-stage patients for whom other treatments had failed.

The Power of Dendritic Cells

Immunotherapy for cancer focuses on boosting the power of the body’s own immune system to fight tumors. Dendritic cells are part of the immune system, serving as advance sentries that recognize the presence of foreign antigens.

Once the dendritic cells process the antigens, they are presented to T cells, another part of the immune system. T cells are effectors that provide a response to stimulus such as bacteria, viruses and other invaders.

Individually, dendritic cells are extremely potent, but the problem is that they’re not usually present in large enough quantities. Dendritic cell vaccines are an effective method of increasing their numbers.

Issels® and the Dendritic Cell Vaccine

In a process called extracorporeal photophoresis, a patient’s blood passes through an ultraviolet light chamber, which provides an immune boosting effect. White blood cells are harvested and cultured into active dendritic cells, then re-injected into the body to trigger an immune response.

Traditional cancer treatments often have side effects because they attack healthy cells along with tumor cells. Dendritic cells can distinguish normal dying cells from cancer cells so the immune system refrains from attacking them.

Personalized Immunotherapy for Cancer at Issels®

Dendritic cell vaccines are only one of the innovative treatments we use for patients with all forms of cancer. Contact us to read and hear testimonials from our many patients who have successfully achieved long-term remission.

Immunotherapy the Cancer Treatment Disrupter

Join Us in the Fight Cancer
Join Us in the Fight Against Cancer

During the last few years, respected political leaders Joe Biden and Jimmy Carter have become active in raising awareness of cancer immunotherapy and the need for research. Now a major figure in the social media and technology field has added his voice and his funding to these efforts.

From Social Networking to Social Responsibility

Sean Parker first made his name as the founder of music-sharing service Napster before serving as the first president of social networking giant Facebook. While that might be enough for most people, Parker has begun a new project that will affect even more individuals in a personal way.

Over the last decade, Parker has generously supported organizations such as Stand Up to Cancer and Cancer Research Institute Immunotherapy Dream Team. Early in 2016, Parker earmarked $250 million from his charitable foundation for a grant to establish the Parker Institute for Cancer Immunotherapy.

The Institute is comprised of seven academic medical centers working in conjunction with more than 50 partners in pharma and biotech. According to Parker, the intent was to “cut down the barriers” that limit the free exchange of information.

Aligning Research and Medicine

Parker was inspired to found the Institute when he noticed a disconnect between academic science and the process of actually bringing treatments to patients. He specifically sees cancer immunotherapy as the “opportunity to disrupt” the gap between what’s possible through technology and what’s actually being accomplished.

Issels®: A Champion for Immunotherapy

Our founder, Dr. Josef M. Issels, was ahead of his time in recognizing the power of cancer immunotherapy. Contact us for more information about our non-toxic integrative programs.

Transformative Impact of Immunotherapy Tops Cancer News

Diverse Hands Holding The Word Cancer
Immunotherapy brings breakthroughs to cancer treatment.

For decades, cancer has been the main focus of innumerable medical researchers. During 2016, immunotherapy for cancer was designated the top advance in the field for the second consecutive year.

The Rapid Rise of Immunotherapy Treatment

The announcement was made in Clinical Cancer Advances 2017, the 12th annual report from the American Society of Clinical Oncology (ASCO). Dr. Daniel F. Hayes, president of ASCO, presented the report to Congress during a recent meeting to request continued funding for cancer research.

According to Dr. Hayes, immunotherapy was a “promising theoretical treatment” less than 10 years ago. In a relatively short span of time, it has become a “standard of care” that has positively affected thousands of patients.

“Immunotherapy 2.0”

Just how much progress has been made in immunotherapy for cancer? Since 2011, a total of 15 immune-targeted therapies have been approved. That success combined with continued improvements in identifying candidates and overcoming resistance mechanisms, led ASCO to dub it “Immunotherapy 2.0.”

Dr. Hayes also stressed the importance of federal funding in maintaining the momentum in cancer research. One prominent development that has made a significant impact is the Cancer Moonshot program. Former Vice President Joe Biden took up the cause after his son Beau’s death from brain cancer.

Issels®: Ahead of the Curve

While the rest of the medical community is embracing the value of immunotherapy for cancer, we have been in the forefront of successfully treating patients by boosting their own immune systems. Visit our website to learn more about cancer vaccines, NK cells and our other non-toxic, individually tailored programs.

 

Highlighting the Issels Cancer Vaccine Treatment Program

Explaining Cancer Vaccines

Vaccines have played a landmark role in medical history, helping to control or eradicate major diseases such as smallpox, measles, flu and polio. This effective form of treatment is also a significant part of our Issels® integrative immunotherapy for cancer programs.

How Do Vaccines Work?

The science behind vaccines may sound counterintuitive. Many vaccines are made from a weakened form of the microorganism that it’s being developed to fight. Once introduced into your system, the vaccines “teach” your immune system to recognize the microorganism as a threat to be attacked and destroyed.

The Issels® Vaccine Program

Our personalized cancer vaccines and cell therapy protocols are created from the patient’s own immune cells and combined with the immunobologic core treatment to target the tumor and its specific microenvironment to optimize their results.

We offer specialized cancer vaccines at the Issels® immuno-oncology center, including Autologous Dendritic Cells Cancer Vaccine, Prostate Cancer Vaccine, as well as the Issels Autologous Vaccine and combine them with the Lymphokine-Activated Killer (LAK) Cell and Natural Killer (NK) Cell protocols.

These vaccines and cell therapies are autologous, meaning they are created from the patient’s own blood. Since the blood cells provide information about the patient’s internal environment, the vaccines can be tailored to target the patient’s unique cancer-fighting properties.

Immunotherapy for Cancer: Boosting Your Body’s Natural Defenses

Cancer vaccines are only one of the non-toxic protocols we use to activate your body’s own immune response against tumors. Contact us today to learn why Issels® has been a leader in immunotherapy for cancer treatments for more than 50 years.