Tag Archives: Immunotherapy

New Treatment Medications Target Biomarkers in Cancer Versus Location

New Treatment Medications Target Biomarkers in Cancer Versus Location
New Treatment Medications Target Biomarkers in Cancer Versus Location

For many years, cancer treatment has traditionally focused on a tumor’s point of origin. A new form of immunotherapy for cancer that targets biomarkers could open the door for more precise and effective treatment of tumors.

Keytruda: A “Presidential” Immunotherapy for Cancer

Keytruda is the brand name of a drug that had previously been used to treat specific types of cancer such as melanoma and Hodgkin’s lymphoma, often during Stage IV. The drug earned public notice when former president Jimmy Carter received successful treatment for brain tumors resulting from Stage IV melanoma.

In May 2017, after five clinical trials, the Federal Drug Administration (FDA) approved Keytruda for use in treating tumors with a particular biomarker, regardless of location. At this point, the new use of Keytruda is limited to patients for whom other therapies have been unsuccessful.

Cutting Through the Red Tape

The new application for Keytruda was fast-tracked under the FDA’s Accelerated Approval program. If there’s a serious condition with no options for treatment, a drug can be approved solely on the basis that it’s been shown to shrink tumors.

Dr. Gwen Nichols, chief medical officer of the Leukemia & Lymphoma Society (LLS), expressed excitement for the new approval process. According to Nichols, it lets researchers focus on the biology of tumor development instead of looking for generic treatments.

Immunotherapy for Cancer Is the Talk of the Medical Community

Doctors and scientists have been buzzing about advancements in immunotherapy, but Issels® has been ahead of the curve for decades. Visit our website to learn more about our innovative immunotherapy for cancer treatments that are personally tailored for your individual needs.

Cancer Risk May Be Identified by the Oral Microbiome

Hold On, You're Telling Me the Bacteria in My Mouth Can Tell What Type of Cancer I Might Have?
Hold On, You’re Telling Me the Bacteria in My Mouth Can Tell What Type of Cancer I Might Have?

For years, the medical community has been telling us that proper oral hygiene is crucial for maintaining good overall health. Scientists are now finding that bacteria in your mouth may actually reveal your risk for different types of cancer.

What Does the Oral Microbiome Tell Us?

Here are some of the major links researchers have uncovered between mouth bacteria and cancer:

• Fusobacterium, which causes bleeding gums, is hundreds of times more prevalent in cancerous cells than in normal cells. This bacteria can trigger colon cancer as well as accelerate growth in any existing colon tumors.

• A study last year discovered the presence of P gingivalis, a bacteria that causes periodontal disease, in 61 percent of patients with esophageal cancer. Researchers also found that people with P gingivalis have a 60 percent higher risk of developing pancreatic cancer.

• Researchers at the University of Buffalo conducted a study in 2015 involving more than 73,000 postmenopausal women. Results showed that women with gum disease were 14 percent more likely to develop breast cancer.

What’s Next?

While conclusions have not been finalized, scientists suspect that the connection occurs when the bloodstream carries bacteria from the mouth to other organs. It’s hoped that further research will enable doctors to determine cancer risk simply by the type of bacteria present in the body.

Personally Tailored Cancer Treatment Based on Your Particular Needs

All cancer cases are different, so why should all cancer treatment be the same? Visit our website to learn why Issels® is the industry leader in state-of-the-art immunotherapy methods such as cancer vaccines and NK cells that are designed for your specific situation.

Could This Bacterial Molecule Stimulate the Immune System to Fight Cancer?

Get The Treatment You Need with Us!
Get The Treatment You Need with Us!

There’s a popular saying that goes, “Everything old is new again.” This may also hold true with immunotherapy for cancer, as researchers explore the possibility of enlisting your body’s ancient defenses against bacterial threats to fight tumors.

Going Back to the Future

A team at Fred Hutchinson Cancer Research Center in Seattle recently conducted a trial of an experimental drug on 15 patients with advanced sarcoma. The drug, known as G100, was based on a molecule called lipopolysaccharide that is carried within certain bacteria.

Lipopolysaccharide is unique to these organisms, so its presence has historically triggered a prompt and powerful inflammatory response. According to scientists, the pathway to this response dates back so far in the evolutionary cycle that it’s nearly identical in all animals.

Over a period of two to three months, participants received an injection of G100 directly into the tumor, along with a course of focused radiation. The injected tumors stopped growing, shrank or even disappeared in 14 of the 15 patients, while tumor growth throughout the body stopped in six of them.

Boosting the Body’s Immune System

Researchers are theorizing that the drug makes the tumor “hot” in terms of activating an immune response aimed specifically at the cancer cells. The next step involves combining G100 injections with an as-yet-undecided immunotherapy agent to see if the treatment can boost the cancer-fighting immune response throughout the body.

Using State-of-the-Art Methods to Fight Cancer

At Issels®, we stay up-to-date on all the latest advancements in immunotherapy for cancer. Contact us to learn more about our non-toxic, integrative treatment programs that are specifically designed for your individual needs.

Immunotherapy Trains Your Body to Fight Its Own Cancer

Immunotherapy Trains Your Body to Fight Its Own Cancer
Immunotherapy Trains Your Body to Fight Its Own Cancer

Your body’s immune system does an amazing job of protecting you from viruses, bacteria and other invaders. Tumor cells are able to avoid detection as foreign bodies, but immunotherapy for cancer is removing this advantage by boosting your body’s natural defenses.

How Cancer “Hijacks” the Immune System

When foreign cells invade your body, they carry proteins called antigens that trigger an immune response. Your system produces antibodies that bind with the antigens, which either neutralize the rogue cells on their own or alert T-cells to attack and destroy them.

While cancer cells also produce antigens, they manage to evade the normal process by hijacking the checkpoints that signal the immune system to attack. The cells remain undetected, allowing them to multiply as they continue to weaken the immune system.

Penetrating the Shield around Cancer Cells

Instead of using external treatments like radiation and chemotherapy to fight tumors, immunotherapy for cancer focuses on boosting the natural abilities of the immune system by “training” it to recognize and attack cancer cells. These methods include:

  • Drugs containing lab-made monoclonal antibodies that bind to cancer cell antigens and block the normal proteins that “disguise” them
  • Vaccines containing proteins that help the immune system recognize antigens on tumor cells

Issels®: A Personalized Approach

Immunotherapy for cancer has become a valuable alternative or supplement to traditional treatments, but each patient’s case is different. We use specialized testing to create an integrative treatment method that addresses your particular needs.

Contact us today to learn why Issels® has been a leader in the successful use of immunotherapy treatments.

New T Cell Tracking May Improve Immunotherapy Treatments

Another Step in Stopping Cancer
New T Cell Tracking May Improve Immunotherapy Treatments

T cells are in the front line of your immune system, multiplying rapidly to attack invading cells throughout your body. Immunotherapy for cancer took a big step forward with a study that found ways to track T cells in order to harness their specific tumor-fighting abilities.

Finding a Needle in a Haystack

Adoptive T cell transfer is a method of treatment in which T cells are harvested from a patient’s body and “groomed” to target cancer cells. They were then multiplied and placed back in the patient’s system where they could attack the tumor.

Unfortunately, there are a couple of roadblocks to this process. It’s difficult to know which of the thousands of different types of T cells are most effective against cancer, and cloning the cells can dilute or alter the tumor-killing properties of the originals.

Solving the Identification Problem

Researchers at Seattle’s Fred Hutchinson Cancer Research Center have discovered a process to help solve the former problem. A method called high throughput T cell receptor sequencing allowed the scientists to tag each T cell receptor with a “barcode,” enabling them to be tracked throughout the body.

The team gained valuable data when they applied the method to 10 patients with metastatic melanoma. Trials are now underway in search of more effective ways to extract and multiply T cells.

Immunotherapy for Cancer: Boosting Your Body’s Natural Defenses

For decades, Issels® has been a pioneer in the use of vaccines, NK cells and other non-toxic immunotherapy for cancer treatments. Visit our website to learn more about our individually tailored programs.

Highlighting Natural Killer Cell Activation through the Issels Immunotherapy Protocol

Worker in a lab
NK Cells and Immunotherapy for Cancer

Natural Killer (NK) cells may sound scary, but they play a valuable role in immunotherapy for cancer. Boosting NK cell levels helps the immune system mount a strong response in order to eliminate tumors.

How Natural Killer Cells Work

When cancer is diagnosed early, treatment has a good success rate. Cases of late-stage cancer are more difficult to treat because the tumor cells have often begun metastasizing throughout the body.

This is where NK cells come in. They fight tumors as well as metastasized cancer cells through production of proteins known as cytokines. In addition, NK cells are so-called because of their capacity to quickly attack foreign bodies without the activation of antibodies.

Another valuable benefit of NK cells is their function in mediating anti-tumor immunity. Studies have shown that mice with reduced levels of NK cells have lowered resistance to metastases and RMA tumor outgrowth.

The Effect of Immunotherapy on NK Cell Levels

An analysis of NK cell counts was done on 129 patients who had gone through the Issels® treatment program. The group of patients ranged across all four Stage classifications and a wide variety of types of tumors.

Each patient’s individual protocols included non-toxic treatments such as immune-stimulants, autohemotherapy, oxidative therapy, enzymatic therapy, phytotherapy, amino acids, detoxification strategies, dietary and life-style changes, as well as emotional support. After approximately three weeks, the group showed an average 48 percent increase in absolute NK cell levels per individual.

Issels®: A Trailblazer in Immunotherapy for Cancer

Our clinic was established to carry on the groundbreaking work of our founder, Dr. Josef M Issels, in the field of immunotherapy for cancer. Contact us for more information about cancer vaccines and other personally tailored treatment programs.