Tag Archives: Immunotherapy

Non-Specific Cancer Immunotherapy Stimulates the Immune System

New Immunotherapy Drugs Can Help Fight Bladder Cancer
Non Targeted Immunotherapy

Targeted cancer therapies work by directly interacting with molecules that aid the growth and spread of cancer cells. Non-specific immunotherapy for cancer acts behind the scenes to bolster the immune system’s ability to fight cancer cells.

Types of Non-Specific Cancer Immunotherapy

Some non-specific therapies are administered on their own, while others are used as adjutants, which means they are used to supplement a main treatment such as a cancer vaccine. A few therapies are used in both ways, depending on the form of cancer being treated.

  • Cytokines are chemicals produced by certain immune cells that play an important role in the growth and activity of other immune cells. They are divided into interleukins, which speed up growth and division of immune cells, and interferons, which aid the body in resisting cancer as well as viral infections.
  • Immune checkpoint inhibitors help the immune system identify cancer cells that use certain proteins to evade detection.
  • Immunomodulating drugs (IMiDs) such as thalidomide, lenalidomide and pomalidomide appear to give a general boost to the immune system, although at present it’s not known exactly how they work.
  • Bacille Calmette-Guérin (BCG) is a germ that triggers the immune system by infecting tissue, although it doesn’t present a threat of serious disease. BCG is one of the earliest forms of immunotherapy for cancer.

Issels® Uses Both Targeted and Non-Specific Immunotherapy

As a leader in the field of immunotherapy for cancer, Issels® uses advanced methods such as vaccines and LAK cells in our individually tailored treatment protocols. Contact us to learn more about how immunotherapy may be the answer for you.

What’s Happening in Immunotherapy Research – Part Two

Advances in Cancer Therapies
Advances in Cancer Therapies

There’s so much exciting news in research involving immunotherapy for cancer that we couldn’t cover it all in one post! Here’s a continuation of our look at new and improved ways scientists are finding to fight cancer.

Cancer Vaccines

Vaccines have long been a promising form of treatment for cancer. One roadblock limiting progress is the ability of cancer cells to fly under the radar of the immune system.

Armed with a growing body of knowledge gained through years of research, scientists are finding methods to boost the effectiveness of vaccines. For example, vaccines are sometimes given in tandem with substances called adjuvants that make the immune response more efficient.

Checkpoint Inhibitors

You may have seen advertisements for products such as nivolumab, which is referred to as an immune checkpoint inhibitor. Cancer cells often elude the immune system by “hiding” behind checkpoint proteins that prevent immune responses against normal cells. Inhibitors target the checkpoints, freeing the immune system to attack cancer cells.

Oncolytic Viruses

Viruses are normally something to avoid, but researchers have found ways to harness their ability to infect and kill cells. Specific modifications alter certain viruses, creating oncolytic viruses that direct their attacks toward cancer cells, while also alerting the immune system to take action.

Is Immunotherapy for Cancer the Answer for You?

For years, Issels® has been a leader in immunotherapy treatments such as cancer vaccines and gene-targeted therapies. Contact us for more information about our non-toxic immunotherapy programs and how they are individually tailored to meet your specific needs.

What’s Happening in Immunotherapy Research – Part One

What's New in Immunotherapy
What’s New in Immunotherapy

As immunotherapy for cancer continues to gain traction in the medical community, researchers around the globe are directing their efforts toward finding new treatment methods and improving existing ones. Here’s a look at some of the exciting developments in immunotherapy treatments that are making news today.

Refining Monoclonal Antibodies

Monoclonal antibodies, or mAbs, are proteins that take advantage of the difference between cancer cells and normal cells. Scientists are exploring ways to make mAbs even more powerful, such as attaching them to drugs or other substances, while making them less likely to trigger an immune response. They are also working on combining mAbs for a more focused attack on tumors.

CAR T-Cells

T-cells, which are part of the immune system, have long been a major subject of immunotherapy research. Recent trials involve removing T-cells from a patient, genetically adding CARs (chimeric antigen receptors), then returning them to the patient’s blood, where they can more precisely target cancer cells. This method has shown particularly promising results in cases featuring advanced forms of leukemia and lymphoma.

Tumor-Infiltrating Lymphocytes

Another approach using T-cells centers on tumor-infiltrating lymphocytes (TILs) found deep within tumors. The TILs are removed from tumor samples and treated with interleukin-2 so they multiply rapidly. Once injected back into the patient, the TILs are better equipped to fight cancer cells.

Issels®: A Pioneer in Immunotherapy Treatments

In our next post, we’ll continue our look at the latest updates on research centering on immunotherapy for cancer. Contact us to learn more about how Issels® has been a leader in personalized, non-toxic immunotherapy protocols.

Monoclonal Antibodies – The Role They Play in Cancer Immunotherapy

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Fighting Cancer with Monoclonal Antibodies

Researchers have developed many new ways to treat cancer, and immunotherapy for cancer has played a large role in their discoveries. Here at Issels®, we’re proud to provide immunotherapy for cancer to our patients as a treatment alternative to chemotherapy and radiation.

In recent discoveries, extensive research has been conducted on Monoclonal Antibodies (MAbs) and the important role they play in treating cancer.

Understanding Antibodies and Their Role in the Body

When your body detects a foreign substance – whether it’s cancer cells or a common infection – your immune system immediately goes to work creating antibodies to fight what doesn’t belong in its environment. The foreign substance is called an antigen, and antibodies will search until it’s been found. Once it’s found, your immune system attacks it.

Researchers have found that by isolating certain antibodies and then reproducing them in a laboratory setting, they are able to target specific cancer cells.

How Monoclonal Antibodies are used in Immunotherapy for Cancer

Just as there are many different types of antigens, there are many types of cancers. MAbs have been shown to be effective against certain types of cancer. The challenge has been that the MAbs must be tailored to go after the right antigen, and that is causing a delay in using this treatment for all types of cancer.

Even so, research is ongoing and experts are hopeful that this new protocol might bring us one step closer to finding a cure.

Here at Issels®, we’re committed to providing you with the best immunotherapy treatment for cancer. If you would like to learn more about how this type of cancer treatment can help you, contact us.

Cancer Survivors: Tips on Living Healthy After Treatment

Cancer Survivors: Tips on Living Healthy After Treatment
Cancer Survivors: Tips on Living Healthy After Treatment

Here at Issels®, whenever we talk with cancer patients about their fears, they’re most concerned about being told that their cancer has returned after being declared “cancer free.” There are actually a lot of things that can be done to reduce your risk of a recurrence and improve your overall health.

Risk Factors for Cancer Survivors

Staying healthy is very important for cancer survivors, and if you fall into certain high-risk groups, there is an elevated chance that your cancer will return. These groups include:

  • Those who are obese or overweight
  • Those who have a heart condition
  • Those who have high blood pressure
  • Those who have been diagnosed with diabetes

While it might seem as though you can’t really do much to change any of these physical ailments or conditions, making small changes to your everyday routine can help. Not only will you feel better overall, but your body will be more equipped to fight off cancer if it does attempt to make a comeback.

Help for Cancer Survivors: Getting Healthy

To get and keep your body in the best possible physical condition, you should consider making these changes to your lifestyle:

  • Start eating healthier foods, and talk with a nutritionist to find out what’s recommended.
  • Add exercise to your daily routine – even a small amount each day can work wonders.
  • Stop all tobacco use.
  • Find healthy ways to deal with stress.
  • Cut down or eliminate the amount of alcohol you drink.

At Issels®, we can help you find the right combination of changes that will help you thrive! Contact us to learn more about immunotherapy.

Cancer Survivors: How to Thrive After Treatment

Close-up of stethoscope and paper on background of doctors and patient working with laptop
How to Thrive After Cancer Treatment

Thanks to cutting-edge treatments like immunotherapy, more and more cancer patients are experiencing positive outcomes. If you’re one of the nearly 15 million cancer survivors in the United States, you may feel a bit adrift as you try to resume your everyday life.

Dr. Joanne Mortimer of the Women’s Cancers Program at City of Hope offers these valuable tips to help you cope and even thrive post-treatment.

Take Care of Your Body and Mind

Cancer is a physical disease that also affects your mental and emotional states. Don’t allow worries about finances, spousal intimacy or other issues to interfere with your recovery. Talk to your doctor and get a referral for a counselor or support group.

Be Realistic

The end of treatment can be similar to other types of loss, where you feel uncertain about where to go from there. Focus on matters you can control, such as following a healthy diet or staying physically active, and you will feel less anxious about the things you can’t.

Educate Your Doctor

The increasing number of cancer survivors is relatively recent, so doctors are also learning about life post-treatment. Don’t be afraid to discuss any symptoms with your doctor, no matter how minor you might think they are. The more information you provide, the better your doctor will be able to assist you and other cancer survivors down the road.

Our Issels® personalized immunotherapy treatments have helped a number of people achieve long-term remission. Visit our website and be inspired by testimonials from patients who have survived cancers of almost every type.