Tag Archives: Prostate Cancer

New Blood Test Identifies Which Prostate Cancer Patients Will Respond Favorably to Specific Medications

New Blood Test Identifies Which Prostate Cancer Patients Will Respond Favorably to Specific Medications
New Blood Test Identifies Which Prostate Cancer Patients Will Respond Favorably to Specific Medications

No two cases of cancer are identical, which makes it a challenge to determine what course of cancer treatment will be most effective. Scientists are excited about a new three-in-one blood test that may open the door for precision treatment of advanced prostate cancer.

Three-Pronged Attack on Prostate Cancer

Professor Johann de Bono, leader of the team at the Institute of Cancer Research in London, explained the three functions of the blood test:

• Blood samples are initially checked for the presence of mutated BRCA genes.

• Once treatment begins, DNA in the blood is monitored to determine whether or not the patient is responding.

• In the final step, blood is tested for signs of evolving cancer that is developing a resistance to drugs.

Overcoming Cancer’s Defense Mechanisms

Cancer cells with BRCA mutations use a specific enzyme to repair themselves, making tumors resistant to treatment. Drugs called Parp inhibitors block these enzymes, causing cancer cells to die off. The blood test helps to identify patients who are most likely to respond to Parp inhibitors.

The Institute of Cancer Research’s chief executive, Paul Workman, praised the test as a simple, inexpensive and non-invasive method to develop precision cancer treatment. While the test currently focuses on prostate cancer, Professor de Bono believes it can be adapted to other forms of cancer in the future.

Issels®: Matching the Right Treatment to the Right Patient

Specialized testing has long been a part of our integrative and personalized cancer treatment programs. Contact us to learn more about how Issels® uses cancer vaccines and other immunotherapy treatments to help patients of all ages.

Medicare Coverage for Early Detection of Cancer – What to Know

Medicare Coverage for Early Detection of Cancer - What to Know
Medicare Coverage for Early Detection of Cancer – What to Know

Navigating the ins and outs of Medicare coverage can be a challenge. Here’s what you need to know about this program and how it applies to screenings for early detection of cancer.

Do All Providers Accept Medicare?

• Participating doctors “accept assignments,” meaning they consider the amount received from Medicare along with your co-pay and deductible as payment in full, resulting in fewer out-of-pocket expenses.

• Non-participating doctors don’t always accept Medicare, so you have to pay out-of-pocket. Medicare will reimburse you for the portions they normally cover, but you still incur sizable expenses for the difference.

• Opt-out doctors don’t participate in Medicare at all, making you fully responsible for all charges.

Medicare Coverage for Cancer Screening

• Annual mammograms are covered for women aged 40 and older, while clinical breast exams (CBE) are covered every two years for women at average risk for breast cancer and once a year for those at high risk.

• Women at average risk for cervical cancer are covered for a Pap test and pelvis exam every two years, while women at high risk are covered annually.

• Colorectal screening is covered for people 50 and over based on risk factors and date of last test.

• For prostate screening, men over age 50 are covered 100 percent for an annual PSA blood test and 80 percent for a digital rectal exam (DRE).

Lung cancer screening is covered once a year if you are between 55 and 77 and have a qualifying history of smoking.

State-of-the-Art Cancer Treatment at Issels®

Our personalized cancer treatment programs have helped many of our patients achieve long-term remission. Visit our website for more information.

Genetic Advances Made in Prostate Cancer Identification

Prostate cancer affects approximately 15 percent of males in their lifetime, and is second only to skin cancer. Recent identification of an overactive gene that accelerates prostate cancer could lead to development of a more effective treatment.

Prostate Cancer Evolves Beyond Drugs

Most prostate tumors are caused by a form of cancer called adenocarcinoma. In advanced stages, adenocarcinoma is treated with drugs that block androgens, the male hormones that fuel the tumor. Unfortunately, the tumors have evolved into a more aggressive, androgen-resistant form called neuroendocrine prostate cancer.

Prostate Cancer Identification
Prostate Cancer Identification

A cross-disciplinary team supported by the Prostate Cancer Foundation discovered a gene known as N-Myc that appears to be the driver behind the change to the more aggressive form. While N-Myc is not usually found in prostate cancer, it has been known to occur in other forms such as neuroblastoma, a rare cancer of the nervous system found in children.

A Pathway to New Treatment Methods

When N-Myc goes into overdrive, it teams up with a protein called EZH2 to block the tumor’s androgen signaling and “flips the switch” on the molecular program that leads to the more aggressive neuroendocrine form. Dr. Jonathan W. Simons, president and CEO of the Prostate Cancer Foundation, calls this a “game-changing” discovery that can enable development of more successful treatments.

Personalized, Non-Toxic Treatments for Prostate Cancer

Issels® offers a wide range of Immunotherapy for Cancer protocols, including vaccines and NK cells that have been used to treat patients with prostate cancer, melanoma, leukemia and all other forms. Contact us today to find out how Immunotherapy for Cancer at Issels® can help you or your loved one.

Prostate Cancer Prevention Starts with Small Lifestyle Changes

Alternative Lung Cancer Treatment
Prostate Cancer Awareness

Prostate cancer claims the lives of over 27,000 men each year. It’s now estimated that one in seven men will contract this deadly disease within their lifetime. The Issels® Centers for Immune-Oncology have good news regarding the fight against prostate cancer. This is one disease that responds well to preventive measures. Prostate cancer prevention starts with small lifestyle changes.

Improve Your Diet

Steer Clear of Processed Foods – these have been shown to increase the risk of developing all cancers. Improving your diet is the first and easiest step you can take to prevent the onset of prostate cancer.

Consume More Vegetablesvegetables contain nutrients that have been shown to improve the body’s ability to combat illness. One easy way to incorporate more vegetables into your diet is to juice green smoothies at home. Include kale, carrots and celery when possible.

Eat More Fish – Fish contains an important element known as omega-3, a fatty acid that has been linked to a reduced chance of getting prostate cancer. When possible, choose wild fish over farmed.

Get More Exercise

Moderate exercise has been shown to protect against all cancers, including prostate cancer. If you only have time for one type of exercise, choose exercises that get your whole body moving over ones that only move portions of your body. For example, walking would be better than bicycling and swimming would be better than weightlifting, as far as prostate cancer prevention is concerned.

When you implement these easy lifestyle changes, you may save more than one life. When your son sees the effort you protect your prostate health, he may adopt his own healthy lifestyle changes.

For questions and to discuss treatment programs for a loved one who may already have prostate cancer we encourage you to contact us at Issels.

Which Type of Prostate Cancer Do You Have? Scientists Find 5 Types

Prostate Cancer In Men
Prostate Cancer In Men

Prostate cancer is the second most common cancer in U.S. men, with 1 in 7 being diagnosed. Experts now say that there are five distinct types of prostate cancer. How can this help you in your prostate cancer battle? Issels® Center for Immuno-Oncology wants you to know…

Identifying the pieces
In the landmark study, samples of healthy and cancerous prostate tissue from over 250 men were analyzed, looking for abnormal chromosomes and measuring the activity of 100 different genes linked to the disease. Tumors of five distinct types were uncovered, each with a unique genetic fingerprint.

Putting the puzzle together
Prior research had identified six of the genes associated with prostate cancer, however the other 94 remained in hiding until brought to light by this recent study.

Solving the puzzle
The findings from this study could dramatically change the way prostate cancer is treated in the future. In identifying characteristics of the tumors, the scientists in the study were able to be more accurate at predicting aggressive, rapidly spreading cancers than today’s tests, such as the PSA test and Gleason score.

The missing piece
Current treatment methods, which result in some patients getting unnecessary treatment (and having to manage side effects) while others with more aggressive forms of prostate cancer often go without the intensive treatments they need will be impacted by this important study.  The study findings could save lives by allowing doctors the opportunity to quickly identify specific cancer subtypes. This specialized classification may allow a more fitting course of treatment for each patient and help those identified with the aggressive classification of prostate cancer to get treatment faster and earlier. Before this typing of prostate cancer tumors can be used to start saving lives however, a larger trial needs to be done.

Looking for a center for immune-oncology that can handle every healthcare variable? Issels® has you covered! Contact us today.

Recent Gene Mutation Discovery Linked to Prostate Cancer Offers New Testing and Treatment Hopes

Cancer Support.
Reducing The Chance of Prostate Cancer

We believe at Issels® Immuno-Oncology that integrative immunotherapy treatment plans are critical for successful patient outcomes; which is why we are so excited about the following prostate cancer risk detection and screening news:

The National Cancer Institute estimates that approximately 27,540 American men will die from prostate cancer this year. Yet, as reported in the New England Journal of Medicine, researchers have finally found their first link between inherited genes and prostate cancer — a HOXB13 gene mutation.

The Details

Researchers took samples from 5,100 prostate cancer patients who were 55 years old or younger (94 families represented) and 1,400 healthy men. After sequencing more than 200 genes, they found the following:

  • 72 men in four families carried the same HOXB13 gene mutation.
  • Only one man in the control group had it.

Although these results aren’t definitive proof that the mutation causes prostate cancer, it does appear to be a factor. The researchers also found two more mutations among African men, but they need a larger sampling to confirm if these mutations also play a role.

The Big Picture

Doctors trace the risk of inherited breast cancer in women through tests that look for mutations of BRCA1 and BRCA2 genes that can contribute to cancer growth. The HOXB13 mutation offers hope that doctors might one day be able to test men for genetic links in a similar fashion.

Since men with the HOXB13 gene mutation carry 10-20 times more risk of getting prostate cancer before they reach 55 years old, the discovery of this gene is a scientific breakthrough. At Issels®, we search for breakthroughs like these every single day. Contact us today for more information!