Prevention Through The Issels Treatment Of Further Recurrence Of A Tumor Of The Mamilla (Nipple) Which Had Recurred 9 Times After Surgery And Had Progressed Towards Malignancy
Patient E.D., Born 1931, file No. 203/55.
40 years no recurrence, patient leading a healthy normal life
TREATMENT HISTORY First Diagnosis | Standard Treatment | Issels Treatment
1948
Papilloma of right nipple (Dr. Roemer, Trier) , surgery
First local recurrence (Dr. Roemer, Trier), surgery
Standard/ Conventional Treatment
1949
Second local recurrence (Dr. Roemer, Trier), surgery
Third local recurrence (Dr. Bauknecht, Trier), surgery
Histology, including 3rd recurrence : No evidence of malignancy
Fourth local recurrence (Dr. Bauknecht, Trier), suspicion of Paget's disease (Dr. Bauknecht, Dr. Jacobs, Trier), surgery
1950
Fifth local recurrence, suspicion of Paget's disease (Prof. Bruehl, Trier, Prof. von Kennel, University of Cologne), surgery
1952
Sixth local recurrence (same physicians), surgery
Beginning Paget's disease-like tissue metamorphosis. (Dr. Berres, Cologne)
1953
Seventh local recurrence (same physicians), surgery
1954
Eighth local recurrence (Dr. Schmuck, Dr. Geiger, Dr. Haaf, Trier), Surgery, Radiation, Chemotherapy.
Suggested amputation of both breasts refused by patient.
August 1955
Admission to Dr. Issels' hospital, with ninth recurrence.
Findings on admission by independent specialists: Pedicled cauliflower- shaped papilloma of the right nipple. Excision.
Histological findings of various sections of the tumor sent to different pathologists: Possibly Paget's cancer (Prof. Singer, Munich) Locally malignant basalioma (Prof. Hueck, Munich) Probably local malignancy (Prof. Gloggengiesser, Munich) Hidradenoma, malignancy in question.
August to October 1955
Ten weeks of Issels Treatment (comprehensive immunotherapy)
With this follow-up treatment after surgical removal of the ninth recurrence, further recurrence and a mutilating surgery could be prevented, as well as the progressive transition into malignancy.
1961
Follow-up
1961
Patient got married and became the mother of 2 healthy children.
Observation until 1995
40 years no recurrence, patient leading a healthy normal life
DISCLAIMER: The extent of the response to treatment varies from patient to patient, even with similar diagnosis as the internal bodily environment is unique to each individual patient.
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