1948
Papilloma of right nipple (Dr. Roemer, Trier) , surgery

First local recurrence (Dr. Roemer, Trier), surgery

1949
Second local recurrence (Dr. Roemer, Trier), surgery

Third local recurrence (Dr. Bauknecht, Trier), surgery

Histology, including 3rd recurrence : No evidence of malignancy
Fourth local recurrence (Dr. Bauknecht, Trier), suspicion of Paget's disease (Dr. Bauknecht, Dr. Jacobs, Trier), surgery

1950
Fifth local recurrence, suspicion of Paget's disease (Prof. Bruehl, Trier, Prof. von Kennel, University of Cologne), surgery

1952
Sixth local recurrence (same physicians), surgery

Beginning Paget's disease-like tissue metamorphosis. (Dr. Berres, Cologne)

1953
Seventh local recurrence (same physicians), surgery

1954
Eighth local recurrence (Dr. Schmuck, Dr. Geiger, Dr. Haaf, Trier), Surgery, Radiation, Chemotherapy.

Suggested amputation of both breasts refused by patient.

August 1955
Admission to Dr. Issels' hospital, with ninth recurrence.

Findings on admission by independent specialists: Pedicled cauliflower- shaped papilloma of the right nipple. Excision.

Histological findings of various sections of the tumor sent to different pathologists: Possibly Paget's cancer (Prof. Singer, Munich) Locally malignant basalioma (Prof. Hueck, Munich) Probably local malignancy (Prof. Gloggengiesser, Munich) Hidradenoma, malignancy in question.

August to October 1955
Ten weeks of Issels Treatment (comprehensive immunotherapy)

With this follow-up treatment after surgical removal of the ninth recurrence, further recurrence and a mutilating surgery could be prevented, as well as the progressive transition into malignancy.

1961

1961
Patient got married and became the mother of 2 healthy children.

Observation until 1995
40 years no recurrence, patient leading a healthy normal life