Arabic Czech Chinese Taiwan French German Hebrew Traditional Hong Kong Indonesian Italian Japanese Malaysian Korean Urdu Polish Russian Spanish Thai  
                    Call toll-free: 1.888.447.7357 | English | Español
Home - Issels Integrative Oncology Issels Integrative Oncology - Treatment Summary
You are here: Home > History

The History of Issels Integrative Immuno-Oncology

Josef M. Issels, M.D., Nov. 21, 1907  -
Feb 11, 1998

Issels Integrative Immuno-Oncology as practiced at our Centers has its origin in Germany.

This comprehensive treatment, with non-toxic immunotherapy as its main pillar, has evolved from the foundation laid by the renowned cancer specialist, Josef M. Issels, M.D., in Germany. He was the founder of the world’s first hospital which grew to 120 patient beds solely dedicated to integrative immunotherapy of advanced and standard therapy-resistant cancers. Immunotherapy is now considered the most advanced cancer treatment.

Issels Integrative Immuno-Oncology stands out for its extensive history of complete long-term tumor remissions of advanced and standard therapy-resistant cancers. It is the treatment of both the cancer tumor and the tumor microenvironment with its pivotal role in cancer progression or regression.

Latest cancer research confirms the importance of the tumor microenvironment.

Government Authorities & Eminent Scientists on Issels

In view of his expertise and results, Dr. Josef Issels was invited to serve as an expert member of the German Federal Government Commission in the Fight against Cancer from 1981 until his retirement in 1987.

John Anderson, M.D., Former Head and Chair of the Department of Medicine at King’s College Hospital Medical School, University of London, England, Former Consultant to the World Health Organization on Oncology, visited the Issels Hospital and confirmed the treatment results. Please read his report here »

In 1987, Dr. Issels retired from his activities in Germany and introduced the Issels Treatment to the Americas.


Upon the retirement from his activities in Germany, Dr. Issels introduced the Issels Integrative Immuno-Oncology to the Americas.






After his death in 1998, Dr. Josef Issels' legacy has been continued with the same integrity and dedication by his wife and collaborator for 40 years, Ilse Marie Issels, and their sons, Dr. Christian N. Issels and Hellmut J. Issels. They have since carried on his work with remarkable results.

More Backround »

© 2015 Issels® Integrative Immuno-Oncology Centers
Privacy Policy | Contact Us | Site Map